TCT-637 A Novel Bioactive and Coating-Free Stent Surface Exhibits a Reduction in Neointimal Hyperplasia by Decreasing Platelet Aggregation and Promoting Endothelialization
The QBM surface significantly reduced neointimal hyperplasia in swine coronaries compared to both BMS and DES, independently from stent design and/or alloy, without adverse vascular healing effects. In-Vitro data indicate that those results may be related to a significant reduction of adherent platelets combined with enhanced neutrophil adhesion, which promote reendothelialization and decrease neointimal hyperplasia by locally regulating acute inflammatory response and endothelial recovery. Therefore, this novel approach may be an effective alternative to DES in reducing clinical in-stent restenosis.
3 University Hospital Zurich, Zurich, Switzerland
4 Harvard-MIT Biomedical Engineering Center, Cambridge, Massachusetts