TCT-637 A Novel Bioactive and Coating-Free Stent Surface Exhibits a Reduction in Neointimal Hyperplasia by Decreasing Platelet Aggregation and Promoting Endothelialization
Lynn Bailey1; Adam Groothuis1; Arik Zucker2; Stefano Buzzi2; Armin Mäder2; Algirdas Ziogas3; Vincent Milleret3; Martin Ehrbar3; Elazer Edelman4
The QBM surface significantly reduced neointimal hyperplasia in swine coronaries compared to both BMS and DES, independently from stent design and/or alloy, without adverse vascular healing effects. In-Vitro data indicate that those results may be related to a significant reduction of adherent platelets combined with enhanced neutrophil adhesion, which promote reendothelialization and decrease neointimal hyperplasia by locally regulating acute inflammatory response and endothelial recovery. Therefore, this novel approach may be an effective alternative to DES in reducing clinical in-stent restenosis.
