Differential protein adsorption of surface treated Nitinol alloys regulates blood activation
K Gegenschatz-Schmid, S Buzzi, J Grossmann, B Roschitzki, D Glück, A Zucker, M Ehrbar
Recent research results were presented at the 2019 Annual Meeting of the Swiss Society for Biomaterials + Regenerative Medicine.
Abstract: Stents were developed for overcoming heart attacks and strokes caused by atherosclerosis and their use extended in recent years to the treatment of aneurysms as flow-diverting stents. Due to interaction with foreign material surfaces and blood flow perturbation, a possible complication of stent implantation is thrombosis (blood clot formation). A novel surface treatment developed by Qvanteq AG renders the surface highly hydrophilic and was shown to reduce platelet adhesion and subsequent clot formation on cobalt-chromium surfaces; this effect was shown to be controlled by differential protein adsorption during blood contact.
Link to abstract.